Objective: To estimate the clinical and cost effectiveness of compress
ion systems for treating venous leg ulcers. Methods: Systematic review
of research. Search of 19 electronic databases including Medline, CIN
AHL, and Embase. Relevant journals and conference proceedings were han
d searched and experts were consulted. Main outcome measures: Rate of
healing and proportion of ulcers healed within a time period. Study se
lection: Randomised controlled trials, published or unpublished, with
no restriction on date or language, that evaluated compression as a tr
eatment for venous leg ulcers. Results: 24 randomised controlled trial
s were included in the review The research evidence was quite weak: ma
ny trials had inadequate sample size and generally poor methodology, C
ompression seems to increase healing rates, Various high compression r
egimens are more effective than low compression, Few trials have compa
red the effectiveness of different high compression systems. Conclusio
ns: Compression systems improve the healing of venous leg ulcers and s
hould be used routinely in uncomplicated venous ulcers. Insufficient r
eliable evidence exists to indicate which system is the most effective
, More good quality randomised controlled trials in association with e
conomic evaluations are needed, to ascertain the most cost effective s
ystem for treating venous leg ulcers.