accurate definition of lung anatomy is the first, necessary step to ob
tain an accurate and early diagnosis of diffuse and focal lung disease
with HRCT. Secondary lobules are visible with conventional CT and HRC
T as polygonal portions of lung parenchyma, surrounded by thin and inc
omplete septa and centred by a dense dot; acini are sometimes visible
as rounded structures with a central dot. Morphological definition of
these structures in normal subjects will greatly help in characterizin
g early signs of parenchymal disease.