THE EFFECTS OF NINJINYOEITO ON CULTURED VENOUS ENDOTHELIAL-CELLS

The effects of Ninjinyoeito on endothelial cells in human umbilical ve ins was examined. We found that Ninjinyoeito accelerates the inhibitio n and decomposition of Endothelin-1 production, which is known to cons trict veins and raise blood pressure, and promote the synthesis of nit ric oxicide which is known to have a vasophypotonic effect. We also fo und that Ninjinyoeito accelerates Interleukin 1 beta (IL-1 beta) produ ction. IL-1 beta is a substance that plays important roles in maintain ing the homeostasis of living organisms in immunity and inflammation, for example, as well as in the production of tissue plasminogen activa tors, which are known to have an anti-thrombotic effect on blood coagu lation and on the fibrinolysis mechanism. Thus, it is suggested that N injinyoeito is effective in accelerating the physiological functions o f human vein endothelial cells in vitro.