Nucleation rates for tunneling processes in Minkowski and de Sitter sp
ace are investigated, taking into account one loop prefactors. In part
icular, we consider the creation of membranes by an antisymmetric tens
or field, analogous to Schwinger pair production.. This can be viewed
as a model for the decay of a false (or true) vacuum at zero temperatu
re in the thin wall limit. Also considered is the spontaneous nucleati
on of strings, domain walls, and monopoles during inflation. The insta
ntons for these processes are spherical world sheets or world lines em
bedded in flat or de Sitter backgrounds. We find the contribution of s
uch instantons to the semiclassical partition function, including the
one loop corrections due to small fluctuations around the spherical wo
rld sheet. We suggest a prescription for obtaining, from the partition
function, the distribution of objects nucleated during inflation. Thi
s can be seen as an extension of the usual formula, valid in flat spac
e, according to which the nucleation rate is twice the imaginary part
of the free energy. For the case of pair production, the results repro
duce those that can be obtained using second quantization methods, con
firming the validity of instanton techniques in de Sitter space. Throu
ghout the paper, both the gravitational field and the antisymmetric te
nsor field are assumed external.