P. Mayorga et al., INTERPRETATION AND PREDICTION OF PLASMA-LEVELS OF PRIMAQUINE FOLLOWING TRANSDERMAL DELIVERY IN SWISS MICE, International journal of pharmaceutics, 155(1), 1997, pp. 99-107
A therapeutic transdermal system based on ethyl cellulose polymer and
matrix diffusion-controlled release of an antimalarial, primaquine (PQ
), was investigated with respect to the in vitro percutaneous penetrat
ion and in vivo skin absorption profile of the drug. In order to corre
late in vitro and in vivo data, pharmacokinetic modelling was performe
d, Thus, the diffusion of the drug through the polymeric device and it
s pharmacokinetics parameters were both considered, Franz-type diffusi
on cells were used for in vitro determinations. In vivo experiments we
re performed with Swiss mice. Drug plasma profiles following transderm
al treatment showed constant primaquine plasma levels, indicating cont
rolled and systemic delivery of the drug over a period of 40 h. (C) 19
97 Elsevier Science B.V.