M. Furuse et al., ACCELERATION OF GRANULOCYTIC CELL RECOVERY IN IRRADIATED MICE BY A SINGLE SUBCUTANEOUS INJECTION OF A HEAT-KILLED LACTOBACILLUS-CASEI PREPARATION, Journal of radiation research, 38(2), 1997, pp. 111-120
Flow cytometric analysis showed that the treatment of irradiated mice
with a heat-killed Lactobacillus casei preparation (LC 9018) accelerat
ed the recovery of granulocytic cell populations in peripheral blood,
spleen and femur bone marrow. The recovery of the lymphocytic cell pop
ulation was not accelerated while the recovery of the B-lymphocytic ce
ll population was inhibited. Histological analysis also showed that th
e LC-9018 treatment markedly enhanced granulopoiesis in the spleen and
bone marrow of irradiated mice. The same LC-9018 treatment significan
tly increased 30-day survival rates of athymic nude mice after lethal
whole-body irradiation. The recovery of the granulocytic cell populati
on in peripheral blood of irradiated athymic nude mice was also accele
rated by LC-9018 treatment. Our results suggest that LC 9018 protected
lethally irradiated mice from bone marrow death by enhancing granulop
oiesis rather than lymphopoiesis and that the contribution of activate
d T lymphocytes to the enhancement of the granulopoiesis was small.