NEOKYOTORPHIN AND NEOKYOTORPHIN-(1-4) - SECRETION BY ERYTHROCYTES ANDREGULATION OF TUMOR-CELL GROWTH

Human erythrocytes release neokyotorphin, the 137-141 fragment of hemo globin alpha-chain into the supernatant of red blood cells primary cul ture, However, the neokyotorphin fragment 1-4 that is formed together with neokyotorphin inside the red blood cells and in various tissues i s not found in the supernatant. Both neokyotorphin and its 1-4 fragmen t were shown to stimulate proliferation of L929 tumor cells. (C) 1997 Federation of European Biochemical Societies.