THE INHIBITORY ACTIVITY OF DIAZINYL-SUBSTITUTED THIOUREA DERIVATIVES ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE

Authors
HEINISCH G MATUSZCZAK B PACHLER S RAKOWITZ D
Citation
G. Heinisch et al., THE INHIBITORY ACTIVITY OF DIAZINYL-SUBSTITUTED THIOUREA DERIVATIVES ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Antiviral chemistry & chemotherapy, 8(5), 1997, pp. 443-446
Citations number
8
Categorie Soggetti
Biology,"Pharmacology & Pharmacy
Journal title
Antiviral chemistry & chemotherapy → ACNP
ISSN journal
09563202
Volume
8
Issue
5
Year of publication
1997
Pages
443 - 446
Database
ISI
SICI code
0956-3202(1997)8:5<443:TIAODT>2.0.ZU;2-C
Abstract
Starting from 2-(2-aminoethyl)pyridine, a series of N-daizinyl-N'-[2-( 2-pyridyl)ethyl]thioureas was prepared via the (2-pyridyl)ethylisothio cyanate and was screened as non-nucleoside human immunodeficiency viru s type 1 reverse transcriptase inhibitors. Derivatives bearing a 3-pyr idazinyl or a 4-pyrimidinyl moiety turned out to be the most potent co mpounds. However, they exhibited less activity than nevirapine or trov irdine.