TEMPERATURE COMPENSATION OF CIRCADIAN-RHYTHMS - CONTROL OF THE PERIODIN A MODEL FOR CIRCADIAN OSCILLATIONS OF THE PER PROTEIN IN DROSOPHILA

Authors
LELOUP JC GOLDBETER A
Citation
Jc. Leloup et A. Goldbeter, TEMPERATURE COMPENSATION OF CIRCADIAN-RHYTHMS - CONTROL OF THE PERIODIN A MODEL FOR CIRCADIAN OSCILLATIONS OF THE PER PROTEIN IN DROSOPHILA, Chronobiology international, 14(5), 1997, pp. 511-520
Citations number
27
Categorie Soggetti
Physiology,"Biology Miscellaneous
Journal title
Chronobiology international → ACNP
ISSN journal
07420528
Volume
14
Issue
5
Year of publication
1997
Pages
511 - 520
Database
ISI
SICI code
0742-0528(1997)14:5<511:TCOC-C>2.0.ZU;2-Z
Abstract
The factors affecting the period are examined in a model for circadian oscillations of the period protein (PER) in Drosophila. The model for the circadian clock is based on multiple phosphorylation of PER and o n the negative feedback exerted by PER on the transcription of the per iod (per) gene. The results are used to address the possible bases of the relative invariance of the period of oscillations with respect to temperature. Such a phenomenon, referred to as temperature compensatio n, represents one of the most conspicuous properties of circadian rhyt hms.