PROPHYLAXIS OF EXPERIMENTAL HTLV-I INFECTION IN CYNOMOLGUS MONKEYS BYPASSIVE-IMMUNIZATION

Authors
AKARI H SUZUKI T IKEDA K HOSHINO H TOMONO T MUROTSUKA T TERAO K ITO H YOSHIKAWA Y
Citation
H. Akari et al., PROPHYLAXIS OF EXPERIMENTAL HTLV-I INFECTION IN CYNOMOLGUS MONKEYS BYPASSIVE-IMMUNIZATION, Vaccine, 15(12-13), 1997, pp. 1391-1395
Citations number
24
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
15
Issue
12-13
Year of publication
1997
Pages
1391 - 1395
Database
ISI
SICI code
0264-410X(1997)15:12-13<1391:POEHII>2.0.ZU;2-Z
Abstract
The protective effect of purified human immunoglobulin against human T -cell leukaemia virus type I (HTLV-I), designated ATLIG on HTLV-I infe ction was examined in cynomolgus monkeys (Macaca fascicularis) as a pr eclinical study. Passive immunization of ATLIG 24 h before challenging HTLV-I protected the monkeys from HTLV-I infection. The result sugges ts that passive immunization of ATLIG could provide safe and sufficien t protection against HTLV-I infection in humans. (C) 1997 Elsevier Sci ence Ltd.