PREPARATION OF N-[C-11]METHYL-2,5-DIMETHOXY-4-METHYLAMPHETAMINE

In order to evaluate the neurobiological mechanism causing the psychog enic effects of N-methyl-2,5-dimethoxy-4-methylamphetamine (MDOM), the C-11 labelled analogue was prepared for application in in vivo PET st udies by the reaction of 2,5-dimethoxy-4-methylamphetamine (DOM) with [C-11]CH3I. The radiochemical yield was determined in dependence on ti me, temperature, solvent and amount of substrate. The best conditions for fast labelling reactions with C-11 on a preparative scale were fou nd to be a reaction time of 10 miutes at 110 degrees C using 1 mg DOM in acetonitrile thus obtaining radiochemical yields of 80% (based on p roduced [C-11]CH3I).