La. Fomenko et al., ANTIOXIDANT VITAMINS DIET DECREASES THE R ATE OF CHROMOSOMAL DAMAGE AND GENIC MUTATION IN IRRADIATED MICE, Izvestia Akademii nauk SSSR. Seria biologiceskaa, (4), 1997, pp. 419-424
Two different methods were used to study the effect of the antioxidant
vitamins mixture (AVM) containing beta-carotene, alpha-tocopherol, as
corbic acid, rutin, and microelements zinc and selenium on mouse resis
tance to acute and chronic irradiation. Micronucleus test demonstrated
that a daily dietary supplement of AVM reliably decreased the rate of
chromosomal damage, namely, X-ray-induced micronuclei in the bone mar
row polychromatophilic erythrocytes of aging mice, but did not induce
micronuclei formation in the young mice. Assay for somatic mutations i
n the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus sho
wed that AVM significantly decreased the rate of genic mutations in mo
use splenocytes after chronic irradiation.