ANTIOXIDANT VITAMINS DIET DECREASES THE R ATE OF CHROMOSOMAL DAMAGE AND GENIC MUTATION IN IRRADIATED MICE

Citation
La. Fomenko et al., ANTIOXIDANT VITAMINS DIET DECREASES THE R ATE OF CHROMOSOMAL DAMAGE AND GENIC MUTATION IN IRRADIATED MICE, Izvestia Akademii nauk SSSR. Seria biologiceskaa, (4), 1997, pp. 419-424
Citations number
47
Categorie Soggetti
Biology
ISSN journal
00023329
Issue
4
Year of publication
1997
Pages
419 - 424
Database
ISI
SICI code
0002-3329(1997):4<419:AVDDTR>2.0.ZU;2-M
Abstract
Two different methods were used to study the effect of the antioxidant vitamins mixture (AVM) containing beta-carotene, alpha-tocopherol, as corbic acid, rutin, and microelements zinc and selenium on mouse resis tance to acute and chronic irradiation. Micronucleus test demonstrated that a daily dietary supplement of AVM reliably decreased the rate of chromosomal damage, namely, X-ray-induced micronuclei in the bone mar row polychromatophilic erythrocytes of aging mice, but did not induce micronuclei formation in the young mice. Assay for somatic mutations i n the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus sho wed that AVM significantly decreased the rate of genic mutations in mo use splenocytes after chronic irradiation.