RADIOLABELING OPTIMIZATION OF -123]-IODO-4-OXO-1,4-DIHYDROQUINOLINE-2-CARBOXYLIC ACID - A POTENTIAL TRACER FOR NMDA SPECT STUDIES

Authors
DUMONT F SLEGERS G
Citation
F. Dumont et G. Slegers, RADIOLABELING OPTIMIZATION OF -123]-IODO-4-OXO-1,4-DIHYDROQUINOLINE-2-CARBOXYLIC ACID - A POTENTIAL TRACER FOR NMDA SPECT STUDIES, Journal of radioanalytical and nuclear chemistry, 218(2), 1997, pp. 239-241
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Analytical","Nuclear Sciences & Tecnology
Journal title
Journal of radioanalytical and nuclear chemistry → ACNP
ISSN journal
02365731
Volume
218
Issue
2
Year of publication
1997
Pages
239 - 241
Database
ISI
SICI code
0236-5731(1997)218:2<239:ROO->2.0.ZU;2-2
Abstract
The synthesis of 7-bromo-5-[I-123]-iodokynurenic acid is described. Th e tracer was prepared using a nucleophilic non-isotopic exchange react ion from the corresponding bromo derivative. Optimisation of the react ion parameters and HPLC purification were performed and the radiotrace r was obtained in a chemical and radiochemical purity > 95% and a spec ific activity of 235 Ci/mu mol.