A number of acute and chronic conditions can lead to the development o
f chronic ventilatory failure, requiring long-term ventilatory support
with a mechanical ventilator. The most commonly encountered reasons f
or such support may include chronic lung diseases, especially chronic
obstructive lung disease (COPD); acute and chronic neuromuscular disea
ses; catastrophic medical. or surgical illnesses; surgery in high-risk
patients; and trauma. It is usually possible to liberate patients fro
m a ventilator in the acute hospital setting. A significant number of
patients, however, remain dependent upon mechanical ventilation for a
considerable period after its initiation. Whatever the cause, long-ter
m mechanical ventilator dependence may be required when it is impossib
le for an individual to maintain adequate alveolar ventilation without
assistance either to survive or, in some, to function with an accepta
ble quality of life. Depending upon the degree to which normal alveola
r ventilation is compromised, patients may need continuous or partial
mechanical ventilatory support. For most patients in the latter situat
ion, nocturnal mechanical ventilation is used to make it possible for
them to function without mechanical support during the day. Unfortunat
ely, a certain number of individuals require full-time mechanical vent
ilation, which has a limited number of options regarding the safest wa
y to sustain it.