M. Rex et al., CSOX21 EXHIBITS A COMPLEX AND DYNAMIC PATTERN OF TRANSCRIPTION DURINGEMBRYONIC-DEVELOPMENT OF THE CHICK CENTRAL-NERVOUS-SYSTEM, Mechanisms of development, 66(1-2), 1997, pp. 39-53
cSax21 is a novel member of the Sox gene family of transcription facto
rs. This gene is a member of the subgroup B, which includes Sox1, Sox2
and Sox3. Although all of these genes are predominantly expressed in
the nervous system, only cSox21 expression is positionally restricted
within the CNS. Longitudinal stripes are seen in the spinal cord and a
more complex pattern is seen in the brain. The timing and position in
which cSox21 stripes of expression appear provides further insight in
to dorsoventral patterning of the CNS. The expression of cSax21, and o
ther genes (such as Delta, Serrate and Pax genes), may play a part in
defining the developmental fate of cells along the dorsoventral axis.
(C) 1997 Elsevier Science Ireland Ltd.