EFFICACY OF TROVAFLOXACIN FOR TREATMENT OF EXPERIMENTAL BACTEROIDES INFECTION IN YOUNG AND SENESCENT MICE

We investigated the efficacy of trovafloxacin, a new quinolone, in com parison with that of cIindamycin in the treatment of intra-abdominal a bscesses caused by Bacteroides fragilis in young and senescent mice, T he development of abscess formation, the number of viable organisms, a nd antibiotic concentrations were measured, and the values for young a nd old mice were compared, Trovafloxacin was well distributed to the t issues in both young and old animals, Although the pharmacokinetics an d concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of yo ung mice and in 73% of old mice, but this difference was not significa nt, This therapeutic response to trovafloxacin was similar to that see n with clindamycin, These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesse s caused by B. fragilis.