COMPARATIVE ANTIANAEROBIC ACTIVITIES OF THE KETOLIDES HMR-3647 (RU-66647) AND HMR-3004 (RU-64004)

Authors
EDNIE LM JACOBS MR APPELBAUM PC
Citation
Lm. Ednie et al., COMPARATIVE ANTIANAEROBIC ACTIVITIES OF THE KETOLIDES HMR-3647 (RU-66647) AND HMR-3004 (RU-64004), Antimicrobial agents and chemotherapy, 41(9), 1997, pp. 2019-2022
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
9
Year of publication
1997
Pages
2019 - 2022
Database
ISI
SICI code
0066-4804(1997)41:9<2019:CAAOTK>2.0.ZU;2-L
Abstract
HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICS a t which 50% of the strains are inhibited (MIC(50)s) of 0.06 to 0.125 m u g/ml and MIC(90)s of 16.0 mu g/ml against 352 anaerobes. MIC(50)s an d MIC(90)s of erythromycin, azithromycin, clarithromycin, and roxithro mycin were 0.5 to 2.0 mu g/ml and 32.0 to >64.0 mu g/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragil is-group anaerobes (other than Fusobacterium mortiferum, Fasobacterium varium and Clostridium difficile).