BACTERICIDAL ACTIVITY AGAINST INTERMEDIATELY CEPHALOSPORIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE IN CEREBROSPINAL-FLUID OF CHILDREN WITH BACTERIAL-MENINGITIS TREATED WITH HIGH-DOSES OF CEFOTAXIME AND VANCOMYCIN

Cerebrospinal fluid (CSF) was taken from 19 children with bacterial me ningitis treated with cefotaxime (300 mg/kg of body weight/day) and va ncomycin (60 mg/kg/day). Median levels of drugs in CSF were smaller th an expected, as follows: 4.4 mu g/ml for cefotaxime, 3.2 mu g/ml for d esacetylcefotaxime, and 1.7 mu g/ml for vancomycin. The median CSF bac tericidal titer against an intermediately cefotaxime-resistant pneumoc occus,vas 1:4. Our data suggest at least an additive interaction betwe en the drugs used in this study.