ANALYSIS OF AHPC GENE-MUTATIONS IN ISONIAZID-RESISTANT CLINICAL ISOLATES OF MYCOBACTERIUM-TUBERCULOSIS

Authors
KELLEY CL ROUSE DA MORRIS SL
Citation
Cl. Kelley et al., ANALYSIS OF AHPC GENE-MUTATIONS IN ISONIAZID-RESISTANT CLINICAL ISOLATES OF MYCOBACTERIUM-TUBERCULOSIS, Antimicrobial agents and chemotherapy, 41(9), 1997, pp. 2057-2058
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
9
Year of publication
1997
Pages
2057 - 2058
Database
ISI
SICI code
0066-4804(1997)41:9<2057:AOAGII>2.0.ZU;2-C
Abstract
The ahpC genes of 57 clinical isolates and one in vitro mutant of Myco bacterium tuberculosis were evaluated by nucleotide sequence analyses. Although compensatory ahpC promoter mutations were identified in 8 ca talase-negative, katG-defective strains, the ahpC genes of 25 catalase -positive, isoniazid-resistant isolates and 25 drug-sensitive strains were not altered.