NEUROCHEMICAL ALTERATIONS AND CURRENT PHARMACOLOGICAL STRATEGIES IN THE TREATMENT OF TRAUMATIC BRAIN INJURY

In recent years, our knowledge concerning pathophysiological changes i n brain metabolism after traumatic brain injury (TBI) has greatly expa nded. This, in turn, has enabled the development of specific pharmacol ogical strategies for the supplementary treatment of brain-injured pat ients with the aim of reducing secondary brain damage. The present art icle focuses on the pathophysiology of TB I and the possibilities for pharmacological intervention. While some of the substances reviewed ar e presently used in the treatment of TBI, others are under experimenta l and clinical evaluation at different stages.