SAFETY AND IMMUNOGENICITY OF A NEW INACTIVATED HEPATITIS-A VACCINE INCONCURRENT ADMINISTRATION WITH A TYPHOID-FEVER VACCINE OR A TYPHOID-FEVER PLUS YELLOW-FEVER VACCINE
R. Dumas et al., SAFETY AND IMMUNOGENICITY OF A NEW INACTIVATED HEPATITIS-A VACCINE INCONCURRENT ADMINISTRATION WITH A TYPHOID-FEVER VACCINE OR A TYPHOID-FEVER PLUS YELLOW-FEVER VACCINE, Advances in therapy, 14(4), 1997, pp. 160-167
Citations number
13
Categorie Soggetti
Medicine, Research & Experimental","Pharmacology & Pharmacy
Two clinical studies were conducted to evaluate the safety and immunog
enicity of concomitant administration of a new inactivated hepatitis A
(HA) vaccine and either a typhoid fever (Vi) vaccine or a combination
of Vi and yellow fever (YF) vaccines. In study 1, 62 healthy adults r
eceived HA + Vi into the deltoid muscle on contralateral sides. In stu
dy 2, 59 healthy adults received HA and a combined Vi/YF vaccine into
the contralateral deltoid muscles. Reactogenicity was evaluated for 14
days following vaccination. Blood samples (for antibody titration) we
re obtained prior to vaccination on days 0 and 28 in study 1 and prior
to vaccination on day 0 and on days 14 and 28 in study 2. The overall
rate of local reactions was 19% at the HA injection site and 75% at t
he Vi injection site in study 1; the rate of systemic reactions was 41
%. In study 2, local reactions occurred at 27% and 78% of the HA and V
i/YF injection sites; the rate of systemic reactions was 42%. All reac
tions were transient. Twenty-eight days after vaccination, the serocon
version rate was 100% for HA antibodies and 90% for the Vi vaccine in
study 1. Rates of seroconversion in study 2 were 100% for the HA vacci
ne, 92% for the Vi vaccine, and 100% for the YF vaccine. Although this
study was not comparative, both tested combinations were safe and imm
unogenic, and their routine use for persons at risk, such as travelers
, can be recommended.