FLOW-INJECTION FLUOROMETRIC ANALYSIS OF SEVERAL AMINOPHENOTHIAZINES BASED ON PHOTOOXIDATION

Flow-injection analysis (LIA) was combined with photochemically induce d fluorescence (PIF) detection for the determination of four aminophen othiazines, including ethopropazine, trifluoperazine, levomepromazine and thioproperazine. The working analytical parameters (flow-rate, inj ected volume, photoreactor length) were optimized. Linear calibration curves were obtained over about two orders of magnitude, with relative standard deviations within the range 1.2-4.5%. Limits of detection an d quantification were, respectively, between 60-90 and 200-400 ng.mL(- 1), according to the compound. The FIA-PIF method was applied to the d etermination of aminophenothiazines in urine samples and pharmaceutica l preparations. Mean recoveries ranged from 87 to 118%, according to t he compound.