PKB AKT - CONNECTING PHOSPHOINOSITIDE 3-KINASE TO CELL-SURVIVAL AND BEYOND/

Authors
MARTE BM DOWNWARD J
Citation
Bm. Marte et J. Downward, PKB AKT - CONNECTING PHOSPHOINOSITIDE 3-KINASE TO CELL-SURVIVAL AND BEYOND/, Trends in biochemical sciences, 22(9), 1997, pp. 355-358
Citations number
41
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
9
Year of publication
1997
Pages
355 - 358
Database
ISI
SICI code
0968-0004(1997)22:9<355:PA-CP3>2.0.ZU;2-4
Abstract
PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homolo gy (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/A kt provides a survival signal that protects cells from apoptosis induc ed by various stresses, perhaps explaining its discovery as a retrovir al oncogene and its amplification in many human tumours.