IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN AND PROGNOSIS OF SURGICALLY RESECTED NON-SMALL-CELL LUNG-CANCER

Authors
QUANTIN X PUJOL JL LEHMANN M SIMONY J SERRE I MICHEL FB
Citation
X. Quantin et al., IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN AND PROGNOSIS OF SURGICALLY RESECTED NON-SMALL-CELL LUNG-CANCER, Cancer detection and prevention, 21(5), 1997, pp. 418-425
Citations number
48
Categorie Soggetti
Oncology
Journal title
Cancer detection and prevention → ACNP
ISSN journal
0361090X
Volume
21
Issue
5
Year of publication
1997
Pages
418 - 425
Database
ISI
SICI code
0361-090X(1997)21:5<418:IDOPPA>2.0.ZU;2-5
Abstract
We analyzed the survival of 89 surgically treated patients presenting non-small-cell lung cancer in regard to the accumulation of p53 protei n as detected by indirect immunoperoxidase reactivity of PAb1801 anti- human p53 protein. Although the well-known factors such as stage group ing, tumor status, and nodal status were found to be prognostic determ inants, the p53 protein accumulation had no effect on either univariat e analysis or multivariate analysis of survival.