GLYCOSYLATION OF SILYBIN

Authors
KREN V KUBISCH J SEDMERA P HALADA P PRIKRYLOVA V JEGOROV A CVAK L GEBHARDT R ULRICHOVA J SIMANEK V
Citation
V. Kren et al., GLYCOSYLATION OF SILYBIN, Journal of the Chemical Society. Perkin transactions. I, (17), 1997, pp. 2467-2474
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
17
Year of publication
1997
Pages
2467 - 2474
Database
ISI
SICI code
0300-922X(1997):17<2467:GOS>2.0.ZU;2-O
Abstract
Silybin glycosides-23-O-beta-glucoside 2b, beta-galactoside 3b, beta-l actoside 4b and beta-maltoside 5b-have been synthesized by different m ethods (Helferich glycosylation, Lewis acid catalysis), Separation of two silybin diastereoisomers in the form of acetylated monoglycosides has been achieved for the first time, These new silybin glycosides are 4-30 times more water-soluble, and their hepatoprotectivity is increa sed compared with that of the parent compound silybin 1.