SYNTHESIS OF A CIS-CONFORMATIONALLY RESTRICTED PEPTIDE-BOND ISOSTERE AND ITS APPLICATION TO THE INHIBITION OF THE HIV-1 PROTEASE

Authors
ABELL AD FOULDS GJ
Citation
Ad. Abell et Gj. Foulds, SYNTHESIS OF A CIS-CONFORMATIONALLY RESTRICTED PEPTIDE-BOND ISOSTERE AND ITS APPLICATION TO THE INHIBITION OF THE HIV-1 PROTEASE, Journal of the Chemical Society. Perkin transactions. I, (17), 1997, pp. 2475-2482
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
17
Year of publication
1997
Pages
2475 - 2482
Database
ISI
SICI code
0300-922X(1997):17<2475:SOACRP>2.0.ZU;2-T
Abstract
A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylami ne peptide bond isostere is reported, This has been used to produce a new class of HIV-1 protease inhibitor.