DNA ON A CHIP - SERVING UP THE GENOME FOR DIAGNOSTICS AND RESEARCH

It is expected that by the year 2003 the entire human genome will be s equenced, providing us with new insight into human disease. The amount of human sequence information that is already available (only a few p ercent of the total) is, however, already much greater than can be rou tinely evaluated with existing, commonly used diagnostic technology. N ew technology based on attaching DNA to a chip for parallel hybridizat ion analysis is generating much interest in both the basic research an d the clinical diagnostic community. It will increase, by orders of ma gnitude, our ability to evaluate an individual's genetic heritage and to conduct basic genetic research. The new technology will be a major advance in screening for genetic diseases, but the ability to treat th ese newly understood genetic defects will lag significantly behind the new-found diagnostic capabilities.