SPINENCIN, A NEW BIS-TETRAHYDROFURAN ACETOGENIN FROM THE SEEDS OF ANNONA-SPINESCENS

A new bis-tetrahydrofuran acetogenin with a C-28/C-29 vicinal diol, sp inencin (1), was isolated from the MeOH extract of Annona spinescens, in addition to the known compounds, almunequin (2), bullatanocin (3), isodesacetyluvaricin (4), squamocin K (5), desacetyluvaricin (6), and neoannonin (7). The structure of 1 was elucidated by spectroscopic met hods including electrospray ionization and high-energy MS/MS and confi rmed by chemical transformation. The ESI-MS/MS of 2 and 3 were also in vestigated, and it was found for 1-3 that very high levels of radical- cationized species were observed in the charge-remote fragmentation (C RF) processes.