STRUCTURE AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 4-ALPHA(HYDROXYMETHYL)-ALPHA-DEMETHYLTERRITREM-B

Authors
PENG FC
Citation
Fc. Peng, STRUCTURE AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 4-ALPHA(HYDROXYMETHYL)-ALPHA-DEMETHYLTERRITREM-B, Journal of natural products, 60(8), 1997, pp. 842-843
Citations number
11
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
8
Year of publication
1997
Pages
842 - 843
Database
ISI
SICI code
0163-3864(1997)60:8<842:SAAAO4>2.0.ZU;2-R
Abstract
The structure of a metabolite produced on incubation of territrem B (1 ) with rat liver microsomes has been established to be 4 alpha-(hydrox ymethyl)-4 alpha-demethylterritrem B (5). Compound 5 was a portent inh ibitor of electric eel acetylcholinesterase (AChE) (E.C. 3.1.1.7).