CAVERNOSOLIDE, A NEW SESTERTERPENE FROM A TYRRHENIAN SPONGE

Authors
DEROSA S CRISPINO A DEGIULIO A IODICE C TOMMONARO G
Citation
S. Derosa et al., CAVERNOSOLIDE, A NEW SESTERTERPENE FROM A TYRRHENIAN SPONGE, Journal of natural products, 60(8), 1997, pp. 844-846
Citations number
14
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
8
Year of publication
1997
Pages
844 - 846
Database
ISI
SICI code
0163-3864(1997)60:8<844:CANSFA>2.0.ZU;2-2
Abstract
Cavernosolide (3a), a new sesterterpene, has been isolated from the Ty rrhenian sponge Fasciospongia cavernosa. The structure was proposed on the basis of spectroscopic data and by chemical transformations. Cave rnosolide showed potent activity (LC50 = 0.37 mu g/mL) in the Artemia salina bioassay and a moderate toxicity (LC50 = 0.75 mu g/mL) in a fis h (Gambusia affinis) lethality assay.