INHIBITION OF BACTERIAL RNA-POLYMERASES - PEPTIDE METABOLITES FROM THE CULTURES OF STREPTOMYCES SP

Authors
MIAO SC ANSTEE MR LAMARCO K MATTHEW J HUANG LHT BRASSEUR MM
Citation
Sc. Miao et al., INHIBITION OF BACTERIAL RNA-POLYMERASES - PEPTIDE METABOLITES FROM THE CULTURES OF STREPTOMYCES SP, Journal of natural products, 60(8), 1997, pp. 858-861
Citations number
21
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
8
Year of publication
1997
Pages
858 - 861
Database
ISI
SICI code
0163-3864(1997)60:8<858:IOBR-P>2.0.ZU;2-7
Abstract
The fermentation culture of a soil strain of Streptomyces has been che mically investigated for its inhibitory activity against RNA polymeras es from the bacteria Escherichia coli and Staphylococcus aureus. The a ctive component was found to be the unusual bicyclodepsipeptide salina mide A (1) recently discovered from a marine Streptomycete. The same e xtract also yielded a new cyclohexapeptide natural product, desotamide (2), the structure elucidation of which was based on amino acid analy sis, detailed spectroscopic data interpretation, and peptide synthesis .