AMELOBLASTIC FIBROSARCOMA ARISING DE-NOVO IN THE MAXILLA

An ameloblastic fibrosarcoma (AFS) arising in the maxilla of a 14-year -old male is described. The tumor originated from the alveolar bone of the right maxilla with no apparent history of pre-existing lesion, Hi stologically, the lesion was composed of benign-appearing epithelial i slands and strands scattered within an exceedingly cellular mass of me senchymal tissue comprising a large number of stellate- and spindle-sh aped fibroblast-like cells with marked pleomorphism. Occasional cement um-like calcification was also noted. Immunohistochemically, the neopl astic mesenchymal cells were positive only for vimentin, whereas the a meloblast-like epithelial component showed a distinctly positive react ion for wide-spectrum keratin and squamous cytokeratin. Clinicopatholo gical features of the current case, as well as previously reported exa mples of AFS originating from the maxilla, are briefly discussed.