Several systemic diseases, including some common ones (eg, diabetes, r
heumatoid arthritis, thyroid disease) can cause symptoms of peripheral
nerve dysfunction. Efficient identification and treatment of the unde
rlying disorder can avoid costly and unnecessary testing. Patients' de
scriptions of symptoms and their onset, specific deficits found on phy
sical examination, and family and medical history provide many clues t
o the cause of the neuropathy. Nerve conduction studies, electromyogra
phy and, when necessary, nerve biopsy serve as complements to clinical
evaluation.