IBS is one of the most common of the gastrointestinal diseases, but it
can be a diagnostic challenge because of the many symptoms that overl
ay with other such diseases. Most common among the symptoms are abdomi
nal pain, a feeling of intestinal distention or bloating, and either d
iarrhea or constipation. Patients may be found to have an exacerbation
of symptoms with stress, and they may have an increased sensitivity t
o bowel distention. History and physical examination findings often ca
n be relied on to make the diagnosis, avoiding overuse of laboratory t
esting. Treatment consists of patient education and support, lifestyle
and dietary changes, and use of several pharmacologic agents for symp
tom relief. Antidepressants are being investigated as a possible addit
ional form of treatment.