Sa. Lauer et al., AN IMMORTALIZED CELL-CULTURE FROM A MALIGNANT MIXED TUMOR OF THE LACRIMAL GLAND, Ophthalmic plastic and reconstructive surgery, 13(3), 1997, pp. 168-173
Tumor cells from a malignant mixed tumor of the lacrimal gland were ma
intained in tissue culture for more than 55 generations. Comparative i
mmunohistochemical analysis was performed on whole tumor sections and
on the tumor cell culture to define the origin of the cells in culture
. The cultured cells expressed cytokeratin, smooth-muscle actin, S-100
protein, and vimentin and were negative for glial fibrillary acidic p
rotein. Tumor sections expressed cytokeratin but were negative for mus
cle-specific actin, vimentin, and glial fibrillary acidic protein. Thr
ough tissue culture studies of salivary gland epithelial neoplasias, w
hich are very similar to lacrimal gland epithelial neoplasias, pluripo
tential stem cells have been identified. Similar tissue culture analys
is of lacrimal gland epithelial neoplasms can be a valuable tool for s
tudying the origin of these uncommon tumors.