GENETIC IMMUNIZATION WITH ADENOASSOCIATED VIRUS VECTORS EXPRESSING HERPES-SIMPLEX VIRUS TYPE-2 GLYCOPROTEIN-B AND GLYCOPROTEIN-D

Authors
MANNING WC PALIARD X ZHOU SZ BLAND MP LEE AY HONG K WALKER CM ESCOBEDO JA DWARKI V
Citation
Wc. Manning et al., GENETIC IMMUNIZATION WITH ADENOASSOCIATED VIRUS VECTORS EXPRESSING HERPES-SIMPLEX VIRUS TYPE-2 GLYCOPROTEIN-B AND GLYCOPROTEIN-D, Journal of virology, 71(10), 1997, pp. 7960-7962
Citations number
17
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
10
Year of publication
1997
Pages
7960 - 7962
Database
ISI
SICI code
0022-538X(1997)71:10<7960:GIWAVV>2.0.ZU;2-2
Abstract
Intramuscular injection of mice with an adeno-associated virus (AAV) v ector expressing herpes simplex virus type 2 glycoprotein B led to the generation of both gB-specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes and anti-gB antibody. AAV-mediat ed immunization was more potent than plasmid DNA or protein in generat ing antibody responses.