Jh. Williams et al., INTRAVENOUS ADMINISTRATION OF HALOPERIDOL TO HEALTHY-VOLUNTEERS - LACK OF SUBJECTIVE EFFECTS BUT CLEAR OBJECTIVE EFFECTS, J PSYCHOPH, 11(3), 1997, pp. 247-252
Healthy volunteers who received i.v. injections of either saline or ha
loperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjec
tive mood, tension, shakiness and the global feeling of having receive
d an active drug. The subjective ratings of volunteers who received ha
loperidol did not differ, overall, from those who received saline. In
contrast, the drug caused clear objective changes in several psycholog
ical tests. I.v. administration of low doses of haloperidol may permit
double-blind testing of the psychological actions of haloperidol in h
ealthy volunteers.