INTRAVENOUS ADMINISTRATION OF HALOPERIDOL TO HEALTHY-VOLUNTEERS - LACK OF SUBJECTIVE EFFECTS BUT CLEAR OBJECTIVE EFFECTS

Citation
Jh. Williams et al., INTRAVENOUS ADMINISTRATION OF HALOPERIDOL TO HEALTHY-VOLUNTEERS - LACK OF SUBJECTIVE EFFECTS BUT CLEAR OBJECTIVE EFFECTS, J PSYCHOPH, 11(3), 1997, pp. 247-252
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences,"Clinical Neurology
Journal title
JOURNAL OF PSYCHOPHARMACOLOGY
ISSN journal
02698811 → ACNP
Volume
11
Issue
3
Year of publication
1997
Pages
247 - 252
Database
ISI
SICI code
0269-8811(1997)11:3<247:IAOHTH>2.0.ZU;2-Y
Abstract
Healthy volunteers who received i.v. injections of either saline or ha loperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjec tive mood, tension, shakiness and the global feeling of having receive d an active drug. The subjective ratings of volunteers who received ha loperidol did not differ, overall, from those who received saline. In contrast, the drug caused clear objective changes in several psycholog ical tests. I.v. administration of low doses of haloperidol may permit double-blind testing of the psychological actions of haloperidol in h ealthy volunteers.