INTRAVENOUS ADMINISTRATION OF HALOPERIDOL TO HEALTHY-VOLUNTEERS - LACK OF SUBJECTIVE EFFECTS BUT CLEAR OBJECTIVE EFFECTS

Healthy volunteers who received i.v. injections of either saline or ha loperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjec tive mood, tension, shakiness and the global feeling of having receive d an active drug. The subjective ratings of volunteers who received ha loperidol did not differ, overall, from those who received saline. In contrast, the drug caused clear objective changes in several psycholog ical tests. I.v. administration of low doses of haloperidol may permit double-blind testing of the psychological actions of haloperidol in h ealthy volunteers.