Al. Malizia et al., DEMONSTRATION OF CLOMIPRAMINE AND VENLAFAXINE OCCUPATION AT SEROTONINREUPTAKE SITES IN MAN IN-VIVO, J PSYCHOPH, 11(3), 1997, pp. 279-281
We describe the use of (CRTI)-C-11-55 and the Multiple Objects Coincid
ences Counter (MOCC) to detect in-vivo binding to peripheral serotonin
reuptake sites (left chest comprising platelet and lung serotonin reu
ptake sites) in man. Displacement and preloading experiments with clom
ipramine and venlafaxine in two healthy volunteers demonstrated that (
CRTI)-C-11-55 binding is decreased in a dose-dependent fashion by both
these drugs which bind to the serotonin transporter. In addition para
llel data from the total head curve (representing (CRTI)-C-11-55 bindi
ng to central serotonin and dopamine (DA) reuptake sites) suggest that
prior blockade of the serotonin transporter may be a useful strategy
to maximize radioactive counts in the head when measuring the DA trans
porter. The MOCC is likely to be useful to determine sequential indice
s of relative serotonin reuptake blockade in patients on treatment.