A STUDY OF THE RETENTION BEHAVIOR OF SOME BENZIMIDAZOLE AND BENZTRIAZOLE DERIVATIVES ON CELLULOSE AND STARCH LAYERS

The retention behavior of two groups of benzimidazole and two groups o f benztriazole derivatives (with amide or amino functional groups) has been studied on rice starch and cellulose thin layers using water-met hanol. (19 + 1-1 + 1) and water-lr-propanol (19 + 1-1 + 1) as mobile p hases. Retention constants, R-M degrees, were determined by extrapolat ion, and overlapping of the extrapolated R-M degrees values from two d ifferent systems show that they are independent of the nature of the o rganic modifier. For the series of compounds investigated very good co rrelation was found between the intercepts and slopes of the TLC equat ions and the retention constants, R-M degrees, the substituent paramet er pi,and biological activity. Retention constants determined for rice starch and cellulose RPTLC systems expressed the lipophilic character of the molecules.