THE RETENTION BEHAVIOR OF SOME ANILIDES ON UNCONVENTIONAL TLC SUPPORTS

The TLC retention behavior of formanilide and I substituted acetanilid es on starch and cellulose layers has been studied using aqueous mobil e phases with methanol, acetonitrile, acetone, and 1-propanol as modif iers, R-Mw values derived by linear extrapolation of the plot of R-M a gainst volume fraction of organic modifier to 100% water are not depen dent on the nature of the organic modifier, Correlation was observed b etween R-Mw values on starch and cellulose layers, Because R-M values are related to the partitioning of the solute molecules in the given s ystem, they can be regarded as a measure of a solute's hydrophobicity, We correlated R-Mw values with the lipophilicity parameters, pi and l ogP; the quadratic equation fit the data well, Multiple regression ana lyses was, furthermore, successfully applied with pi, sigma, and HD as independent variables? suggesting that the electronic properties and hydrogen bonding of the substituent participate in the retention mecha nism.