STUDY OF DIFFERENT CRITERIA FOR THE SELECTION OF A RUGGED OPTIMUM IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OPTIMIZATION

Authors
DEAGUIAR PF VANDERHEYDEN Y MASSART DL
Citation
Pf. Deaguiar et al., STUDY OF DIFFERENT CRITERIA FOR THE SELECTION OF A RUGGED OPTIMUM IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OPTIMIZATION, Analytica chimica acta, 348(1-3), 1997, pp. 223-235
Citations number
25
Categorie Soggetti
Chemistry Analytical
Journal title
Analytica chimica acta → ACNP
ISSN journal
00032670
Volume
348
Issue
1-3
Year of publication
1997
Pages
223 - 235
Database
ISI
SICI code
0003-2670(1997)348:1-3<223:SODCFT>2.0.ZU;2-1
Abstract
Some criteria to select acceptably good and rugged conditions when opt imising separations in High Performance Liquid Chromatography (HPLC) a re discussed and evaluated. These criteria take into account the separ ation between the least separated pair of peaks, and the ruggedness of the optimisation criterion around each possible optimum. It is also s hown that the optimal conditions selected by the criteria are also Par eto-optimal and in agreement with the ones selected when applying Derr inger's desirability function.