NEW PYRROLIDIN-2-OXOCARBOXYLIC, PIPERIDIN-2-OXOCARBOXYLIC AND AZEPIN-2-OXOCARBOXYLIC ACID-ESTERS ARE PREFERENTIAL M(1)-MUSCARINIC, M(3)-MUSCARINIC ANTAGONISTS - SYNTHESIS AND BRONCHOSPASMOLYTIC ACTIVITY

Authors
CEREDA E EZHAYA A BELLORA E SCHIAVI GB SAGRADA A DOODS HN DONETTI A
Citation
E. Cereda et al., NEW PYRROLIDIN-2-OXOCARBOXYLIC, PIPERIDIN-2-OXOCARBOXYLIC AND AZEPIN-2-OXOCARBOXYLIC ACID-ESTERS ARE PREFERENTIAL M(1)-MUSCARINIC, M(3)-MUSCARINIC ANTAGONISTS - SYNTHESIS AND BRONCHOSPASMOLYTIC ACTIVITY, European journal of medicinal chemistry, 29(6), 1994, pp. 411-421
Citations number
21
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
29
Issue
6
Year of publication
1994
Pages
411 - 421
Database
ISI
SICI code
0223-5234(1994)29:6<411:NPPAA>2.0.ZU;2-5
Abstract
A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substi tuted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were syn thesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M(1) and M(3) receptor subtypes an d an interesting activity profile in vivo. A potential use as selectiv e bronchospasmolytic agents has been suggested for selected compounds.