CALCULATION OF CHROMATOGRAPHIC PARAMETERS BY MOLECULAR TOPOLOGY - SULPHAMIDES

This investigation was undertaken to test the ability of the molecular connectivity model to predict R(F) values in thin-layer chromatograph y (TLC) for a group of sulphamides using multi-variable regression equ ations with multiple correlation coefficients, standard error of estim ate, F-Snedecor function values and Student's t-test as criteria of fi t. Regression analyses showed that the molecular connectivity model pr edicts the values for this property in different silica gel stationary phases and different polar mobile phases. Corresponding stability and random studies were made on the selected prediction models which conf irmed their goodness of fit. The results also demonstrated that differ ent structural features determine the R(F) values in TLC of sulphamide s.