ANTAGONISM OF P2X RECEPTORS IN GUINEA-PIG VAS-DEFERENS BY DIINOSINE PENTAPHOSPHATE

Authors
HOYLE CHV PINTOR J GUALIX J MIRASPORTUGAL MT
Citation
Chv. Hoyle et al., ANTAGONISM OF P2X RECEPTORS IN GUINEA-PIG VAS-DEFERENS BY DIINOSINE PENTAPHOSPHATE, European journal of pharmacology, 333(2-3), 1997, pp. 1-2
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
333
Issue
2-3
Year of publication
1997
Pages
1 - 2
Database
ISI
SICI code
0014-2999(1997)333:2-3<1:AOPRIG>2.0.ZU;2-A
Abstract
Diinosine pentaphosphate (Ip(5)I) antagonized contractions, mediated v ia P2X receptors, evoked by diadenosine pentaphosphate (Ap(5)A) and AT P in the guinea-pig isolated vas deferens with pA(2) values of 6.4 +/- 0.17 (10 d.f.) and 6.5 +/- 0.10 (10 d.f.), respectively. Ip(5)I (30 m u M) did not affect contractile responses evoked by noradrenaline. Ip( 5)I (up to 100 mu M) did not antagonize P2Y receptors in the guinea-pi g taenia coli, nor P1 or P2 receptors in the guinea-pig left atrium. ( C) 1997 Elsevier Science B.V.