Ja. Whyte et al., A COMPARISON OF ELTANOLONE AND PROPOFOL ANESTHESIA FOR MINOR GYNECOLOGICAL SURGERY, European journal of anaesthesiology, 14(5), 1997, pp. 499-504
We have used eltanolone and propofol to induce anaesthesia and by inte
rmittent injection to supplement nitrous oxide during maintenance in 6
7 patients undergoing minor gynaecological surgery. This study was a c
ontrolled randomized phase III with two parallel groups and a blinded
assessment of post-operative recovery. Complications during induction
and maintenance were few. Urticaria occurred in two patients given elt
anolone and in none of those given propofol. Time to orientation and t
ime to eye opening were significantly shorter in the propofol group (P
< 0.001). Systolic and diastolic blood pressure decreased in both gro
ups but the decrease was significantly greater in the propofol group (
P < 0.005 systolic blood pressure; P < 0.001 diastolic blood pressure)
. Heart rate decreased significantly in the propofol group (P < 0.002)
. We conclude that eltanolone anaesthesia is associated with a greater
haemodynamic stability than propofol anaesthesia but that early recov
ery occurs more slowly.