THE CHICKEN CCAAT ENHANCER BINDING-PROTEIN ALPHA-GENE - CLONING, CHARACTERIZATION AND TISSUE DISTRIBUTION/

Authors
CALKHOVEN CF GRINGHUIS SI AB G
Citation
Cf. Calkhoven et al., THE CHICKEN CCAAT ENHANCER BINDING-PROTEIN ALPHA-GENE - CLONING, CHARACTERIZATION AND TISSUE DISTRIBUTION/, Gene, 196(1-2), 1997, pp. 219-229
Citations number
64
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
196
Issue
1-2
Year of publication
1997
Pages
219 - 229
Database
ISI
SICI code
0378-1119(1997)196:1-2<219:TCCEBA>2.0.ZU;2-8
Abstract
We present the cloning and sequencing of the gene encoding the chicken CCAAT/Enhancer Binding Protein alpha (cC/EBP alpha). The coding regio n and 1.5 kb of 5' flanking DNA form a CpG island. Comparison of the c hicken C/EBP alpha sequence to the homologous proteins of other specie s reveals several evolutionary conserved regions. cC/EBP alpha mRNA ex pression is restricted to a subset of tissues with high expression in liver, lung and small intestine. Recombinant cC/EBP alpha binds to its cognate C/EBP binding site as a homodimer or as a heterodimer with th e related cC/EBP beta/NF-M. (C) 1997 Elsevier Science B.V.