SYNTHESIS AND CONFORMATION OF 3'-O,4'-C-METHYLENERIBONUCLEOSIDES, NOVEL BICYCLIC NUCLEOSIDE ANALOGS FOR 2',5'-LINKED OLIGONUCLEOTIDE MODIFICATION

Authors
OBIKA S MORIO K NANBU D IMANISHI T
Citation
S. Obika et al., SYNTHESIS AND CONFORMATION OF 3'-O,4'-C-METHYLENERIBONUCLEOSIDES, NOVEL BICYCLIC NUCLEOSIDE ANALOGS FOR 2',5'-LINKED OLIGONUCLEOTIDE MODIFICATION, Chemical communications, (17), 1997, pp. 1643-1644
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
17
Year of publication
1997
Pages
1643 - 1644
Database
ISI
SICI code
1359-7345(1997):17<1643:SACO3N>2.0.ZU;2-W
Abstract
Novel bicyclic nucleoside analogues 3'-O,4'-C-methylene-ribonucleoside s 1 are conveniently prepared starting from uridine; the sugar puckeri ng of 1 is found to be nearly in the S-conformation by means of PM3 ca lculations and H-1 NMR studies.