Adverse reactions to seafood are common and may cause many types of sy
mptoms that are difficult to define. The nature of these reactions are
variable including allergic and toxic reactions as well as infectious
diseases. The differentiation between these entities is essential in
choosing therapy. We describe 9 patients with IgE mediated allergic re
actions due to crustaceans and fish diagnosed from case history, clini
cal findings, skin tests and specific IgE antibodies. Most symptoms of
a IgE mediated allergic reaction appear within 30 minutes after inges
tion. Characteristic clinical features may include an urticarial rash,
gastrointestinal symptoms and even anaphylaxis. In this case immediat
e therapy with intravenous glucocorticoids, antihistamine and perhaps
subcutaneous epinephrine is required.