PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES IN MITOCHONDRIAL ENCEPHALOMYOPATHY

Periodic lateralized epileptiform discharges (PLEDs) were transiently recorded during the acute phase of cerebral stroke-like episodes in th ree patients with mitochondrial encephalomyopathy (MEM). One of the pa tients developed stroke-like episodes three times, always accompanied by PLEDs. These discharges were recorded from the hemisphere responsib le for the stroke-like episodes or from the more severely affected hem isphere when bilateral hemispheres were affected. Although PLEDs have been rarely reported in MEM, this disease should be considered as a di fferential diagnosis of cerebral infarction with PLEDs. (C) 1997 Elsev ier Science Ireland Ltd.