C. Gronfier et al., TEMPORAL RELATIONSHIPS BETWEEN PULSATILE CORTISOL SECRETION AND ELECTROENCEPHALOGRAPHIC ACTIVITY DURING SLEEP IN MAN, Electroencephalography and clinical neurophysiology, 103(3), 1997, pp. 405-408
A temporal link between slow wave sleep and low or decreasing cortisol
release has been previously demonstrated. This relationship was re-ev
aluated in 15 healthy male subjects using spectral analysis of their s
leep electroencephalogram (EEG). EEG activity in the delta, theta, alp
ha and beta bands was cross-correlated with cortisol secretory rates a
t 10-min intervals. For the period of pulsatile cortisol secretion, an
inverse relationship was found with the delta band with an average cr
oss-correlation coefficient of -0.505 (P < 0.0001). Variations in cort
isol secretory rates coincided with or anticipated opposite variations
in delta wave activity by 10 or 20 min. A significant positive correl
ation was found with theta activity, but alpha and beta bands did not
elicit any systematic association with cortisol profiles. These result
s demonstrate a temporal association between cortisol secretory pulses
and delta wave activity in man, suggesting the existence of a central
control common to both variables. (C) 1997 Elsevier Science Ireland L
td.